IL-12 upregulates TIM-3 expression and induces T cell exhaustion in patients with follicular B cell non-Hodgkin lymphoma

The cytokine IL-12 induces IFN-γ production by T and NK cells. In preclinical models, it contributes to antitumor immunity. However, in clinical testing, it has shown limited benefit in patients with any one of a variety of malignancies. Moreover, in a clinical trial testing a combination of IL-12 a...

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Main Authors: Yang, Zhi-Zhang, Grote, Deanna M., Ziesmer, Steven C., Niki, Toshiro, Hirashima, Mitsuomi, Novak, Anne J., Witzig, Thomas E., Ansell, Stephen M.
格式: Artigo
語言:Inglês
出版: American Society for Clinical Investigation 2012
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3314462/
https://ncbi.nlm.nih.gov/pubmed/22426209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI59806
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