Metformin Prevents the Development of Chronic Heart Failure in the SHHF Rat Model

Insulin resistance is a recently identified mechanism involved in the pathophysiology of chronic heart failure (CHF). We investigated the effects of two insulin-sensitizing drugs (metformin and rosiglitazone) in a genetic model of spontaneously hypertensive, insulin-resistant rats (SHHF). Thirty SHH...

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Detalhes bibliográficos
Main Authors: Cittadini, Antonio, Napoli, Raffaele, Monti, Maria Gaia, Rea, Domenica, Longobardi, Salvatore, Netti, Paolo Antonio, Walser, Marion, Samà, Mariateresa, Aimaretti, Gianluca, Isgaard, Jörgen, Saccà, Luigi
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2012
Assuntos:
Pharmacology and Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3314362/
https://ncbi.nlm.nih.gov/pubmed/22344560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db11-1132
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