Sequential delivery of BMP-2 and IGF-1 using a chitosan gel with gelatin microspheres enhances early osteoblastic differentiation

The purpose of this study was to develop and characterize a chitosan gel/gelatin microspheres (MSs) dual delivery system for sequential release of bone morphogenetic protein-2 (BMP-2) and insulin-like growth factor-1 (IGF-1) to enhance osteoblast differentiation in vitro. We made and characterized t...

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Bibliographic Details
Main Authors: Kim, Sungwoo, Kang, Yunqing, Krueger, Chad A., Sen, Milan, Holcomb, John B., Chen, Di, Wenke, Joseph C., Yang, Yunzhi
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3314097/
https://ncbi.nlm.nih.gov/pubmed/22293583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.actbio.2012.01.009
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