Ligation Tunes Protein Reactivity in an Ancient Haemoglobin: Kinetic Evidence for an Allosteric Mechanism in Methanosarcina acetivorans Protoglobin

Protoglobin from Methanosarcina acetivorans (MaPgb) is a dimeric globin with peculiar structural properties such as a completely buried haem and two orthogonal tunnels connecting the distal cavity to the solvent. CO binding to and dissociation from MaPgb occur through a biphasic kinetics. We show th...

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Main Authors: Abbruzzetti, Stefania, Tilleman, Lesley, Bruno, Stefano, Viappiani, Cristiano, Desmet, Filip, Van Doorslaer, Sabine, Coletta, Massimo, Ciaccio, Chiara, Ascenzi, Paolo, Nardini, Marco, Bolognesi, Martino, Moens, Luc, Dewilde, Sylvia
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science 2012
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Research Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3313925/
https://ncbi.nlm.nih.gov/pubmed/22479420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0033614
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