Anti-phospholipid induced murine fetal loss: novel protective effect of a peptide targeting the β2glycoprotein I phospholipid-binding site. Implications for human fetal loss

β(2) glycoprotein I (β2GPI)-dependent anti-phospholipid antibodies (aPL) induce thrombosis and affect pregnancy. The CMV-derived synthetic peptide TIFI mimics the PL-binding site of β2GPI and inhibits β2GPI cell-binding in vitro and aPL-mediated thrombosis in vivo. Here we investigated the effect of...

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Main Authors: de la Torre, Yeny Martinez, Pregnolato, Francesca, D’Amelio, Fabio, Grossi, Claudia, DiSimone, Nicoletta, Pasqualini, Fabio, Nebuloni, Manuela, Chen, Pojen, Pierangeli, Silvia, Bassani, Niccolò, Ambrogi, Federico, Borghi, Maria-Orietta, Vecchi, Annunciata, Locati, Massimo, Meroni, Pier-Luigi
Format: Artigo
Sprog:Inglês
Udgivet: 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3313005/
https://ncbi.nlm.nih.gov/pubmed/22196923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaut.2011.11.009
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