Impact of hemochromatosis gene (HFE) mutations on epithelial ovarian cancer risk and prognosis

Cancer cells require large amounts of micronutrients, particularly iron, for their rapid growth and frequent divisions. Cellular iron uptake is regulated by the transferrin receptor and the hemochromatosis protein (HFE) system. Two frequent mutations in the HFE gene, H63D and C282Y, are associated w...

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Hauptverfasser: Gannon, Philippe O., Medelci, Sanae, Le Page, Cécile, Beaulieu, Martin, Provencher, Diane M., Mes-Masson, Anne-Marie, Santos, Manuela M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3312916/
https://ncbi.nlm.nih.gov/pubmed/20669231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.25577
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