Impact of hemochromatosis gene (HFE) mutations on epithelial ovarian cancer risk and prognosis

Cancer cells require large amounts of micronutrients, particularly iron, for their rapid growth and frequent divisions. Cellular iron uptake is regulated by the transferrin receptor and the hemochromatosis protein (HFE) system. Two frequent mutations in the HFE gene, H63D and C282Y, are associated w...

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Bibliographic Details
Main Authors: Gannon, Philippe O., Medelci, Sanae, Le Page, Cécile, Beaulieu, Martin, Provencher, Diane M., Mes-Masson, Anne-Marie, Santos, Manuela M.
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3312916/
https://ncbi.nlm.nih.gov/pubmed/20669231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.25577
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