The Impact of Nonlinear Smoking Effects on the Identification of Gene-by-Smoking Interactions in COPD Genetics Studies

BACKGROUND: The identification of gene-by-environment interactions is important to understand the genetic basis of chronic obstructive pulmonary disease (COPD). Many COPD genetic association analyses assume a linear relationship between pack-years of smoking exposure and FEV(1); however, this assump...

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Päätekijät: Castaldi, P.J., Demeo, D.L, Hersh, C.P., Lomas, D.A., Soerheim, I.C., Gulsvik, A., Bakke, P., Rennard, Stephen, Pare, Peter, Vestbo, Jørgen, Silverman, E.K.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2010
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3312798/
https://ncbi.nlm.nih.gov/pubmed/21163806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/thx.2010.146118
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