eNOS Deficiency Acts through Endothelin to Aggravate sFlt-1–Induced Pre-Eclampsia–Like Phenotype

Excess soluble fms-like tyrosine kinase 1 (sFlt-1) of vascular endothelial growth factor receptor 1 secreted from the placenta causes pre-eclampsia–like features by antagonizing vascular endothelial growth factor signaling, which can lead to reduced endothelial nitric oxide synthase (eNOS) activity;...

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Autori principali: Li, Feng, Hagaman, John R., Kim, Hyung-Suk, Maeda, Nobuyo, Jennette, J. Charles, Faber, James E., Karumanchi, S. Ananth, Smithies, Oliver, Takahashi, Nobuyuki
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Nephrology 2012
Soggetti:
Basic Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3312503/
https://ncbi.nlm.nih.gov/pubmed/22282588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2011040369
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