Oxidative-stress-induced nuclear to cytoplasmic relocalization is required for Not4-dependent cyclin C destruction

The yeast cyclin-C–Cdk8p kinase complex represses the transcription of a subset of genes involved in the stress response. To relieve this repression, cyclin C is destroyed in cells exposed to H(2)O(2) by the 26S proteasome. This report identifies Not4p as the ubiquitin ligase mediating H(2)O(2)-indu...

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Bibliographic Details
Main Authors: Cooper, Katrina F., Scarnati, Matthew S., Krasley, Elizabeth, Mallory, Michael J., Jin, Chunyan, Law, Michael J., Strich, Randy
Format: Artigo
Language:Inglês
Published: Company of Biologists 2012
Subjects:
Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3311932/
https://ncbi.nlm.nih.gov/pubmed/22421358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.096479
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