Purkinje Cell-Specific Ablation of Ca(V)2.1 Channels is Sufficient to Cause Cerebellar Ataxia in Mice

The Cacna1a gene encodes the α(1A) subunit of voltage-gated Ca(V)2.1 Ca(2+) channels that are involved in neurotransmission at central synapses. Ca(V)2.1-α(1)-knockout (α1KO) mice, which lack Ca(V)2.1 channels in all neurons, have a very severe phenotype of cerebellar ataxia and dystonia, and usuall...

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Détails bibliographiques
Auteurs principaux: Todorov, Boyan, Kros, Lieke, Shyti, Reinald, Plak, Petra, Haasdijk, Elize D., Raike, Robert S., Frants, Rune R., Hess, Ellen J., Hoebeek, Freek E., De Zeeuw, Chris I., van den Maagdenberg, Arn M. J. M.
Format: Artigo
Langue:Inglês
Publié: Springer-Verlag 2011
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Original Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3311848/
https://ncbi.nlm.nih.gov/pubmed/21870131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12311-011-0302-1
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