MGMT promoter methylation in gliomas-assessment by pyrosequencing and quantitative methylation-specific PCR

BACKGROUND: Methylation of the O(6)-methylguanine-DNA methyltransferase (MGMT) gene promoter is a favorable prognostic factor in glioblastoma patients. However, reported methylation frequencies vary significantly partly due to lack of consensus in the choice of analytical method. METHOD: We examined...

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Main Authors: Håvik, Annette Bentsen, Brandal, Petter, Honne, Hilde, Dahlback, Hanne-Sofie Spenning, Scheie, David, Hektoen, Merete, Meling, Torstein Ragnar, Helseth, Eirik, Heim, Sverre, Lothe, Ragnhild A, Lind, Guro Elisabeth
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2012
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3311573/
https://ncbi.nlm.nih.gov/pubmed/22390413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-10-36
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