miR-27b controls venous specification and tip cell fate

We discovered that miR-27b controls 2 critical vascular functions: it turns the angiogenic switch on by promoting endothelial tip cell fate and sprouting and it promotes venous differentiation. We have identified its targets, a Notch ligand Delta-like ligand 4 (Dll4) and Sprouty homologue 2 (Spry2)....

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Detalhes bibliográficos
Main Authors: Biyashev, Dauren, Veliceasa, Dorina, Topczewski, Jacek, Topczewska, Jolanta M., Mizgirev, Igor, Vinokour, Elena, Reddi, Alagarsamy L., Licht, Jonathan D., Revskoy, Sergei Y., Volpert, Olga V.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2012
Assuntos:
Vascular Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3311282/
https://ncbi.nlm.nih.gov/pubmed/22207734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-07-370635
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