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Laminin-α(1) LG4–5 domain binding to dystroglycan mediates muscle cell survival, growth, and the AP-1 and NF-κB transcription factors but also has adverse effects

In our previous studies, we showed laminin binds α-dystroglycan in the dystrophin glycoprotein complex and initiates cell signaling pathways. Here, differentiated C2C12 myocytes serve as a model of skeletal muscle. C2C12 cells have a biphasic response to the laminin-α(1) laminin globular (LG) 4–5 do...

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Bibliografske podrobnosti
Main Authors: Zhou, Yan Wen, Munoz, Jesus, Jiang, Daifeng, Jarrett, Harry W.
Format: Artigo
Jezik:Inglês
Izdano: American Physiological Society 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3311240/
https://ncbi.nlm.nih.gov/pubmed/22159078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00118.2011
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