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1-[4-(2-Aminoethoxy)phenylcarbonyl]-3,5-bis-(benzylidene)-4-oxopiperidines: A novel series of highly potent revertants of P-glycoprotein associated multidrug resistance

The 1-[4-(2-aminoethoxy)phenylcarbonyl]-3,5-bis-(benzylidene)-4-oxopiperidines 5–8 are a novel cluster of highly potent P-glycoprotein dependent multidrug resistance (MDR) revertants. Using a concentration of 4 μg/mL, these compounds possess 11–43 times the potency of verapamil in reversing MDR in m...

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Main Authors: Das, Umashankar, Molnár, Joseph, Baráth, Zoltán, Bata, Zsuzsanna, Dimmock, Jonathan R.
格式: Artigo
語言:Inglês
出版: 2008
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3310923/
https://ncbi.nlm.nih.gov/pubmed/18513966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2008.05.034
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