Blockade of interleukin-6 signaling inhibits the classic pathway and promotes an alternative pathway of macrophage activation after spinal cord injury in mice

BACKGROUND: Recent in vivo and in vitro studies in non-neuronal and neuronal tissues have shown that different pathways of macrophage activation result in cells with different properties. Interleukin (IL)-6 triggers the classically activated inflammatory macrophages (M1 phenotype), whereas the alter...

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Bibliographic Details
Main Authors: Guerrero, Alexander Rodriguez, Uchida, Kenzo, Nakajima, Hideaki, Watanabe, Shuji, Nakamura, Masaya, Johnson, William EB, Baba, Hisatoshi
Format: Artigo
Language:Inglês
Published: BioMed Central 2012
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3310810/
https://ncbi.nlm.nih.gov/pubmed/22369693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-9-40
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