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Imbalance of heterologous protein folding and disulfide bond formation rates yields runaway oxidative stress
BACKGROUND: The protein secretory pathway must process a wide assortment of native proteins for eukaryotic cells to function. As well, recombinant protein secretion is used extensively to produce many biologics and industrial enzymes. Therefore, secretory pathway dysfunction can be highly detrimenta...
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| 主要な著者: | , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
BioMed Central
2012
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3310788/ https://ncbi.nlm.nih.gov/pubmed/22380681 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1741-7007-10-16 |
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