Effects of Celecoxib on Prostanoid Biosynthesis and Circulating Angiogenesis Proteins in Familial Adenomatous Polyposis

Vascular cyclooxygenase (COX)-2-dependent prostacyclin (PGI(2)) may affect angiogenesis by preventing endothelial activation and platelet release of angiogenic factors present in platelet α-granules. Thus, a profound inhibition of COX-2-dependent PGI(2) might be associated with changes in circulatin...

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Detalhes bibliográficos
Main Authors: Dovizio, Melania, Tacconelli, Stefania, Ricciotti, Emanuela, Bruno, Annalisa, Maier, Thorsten Jürgen, Anzellotti, Paola, Di Francesco, Luigia, Sala, Paola, Signoroni, Stefano, Bertario, Lucio, Dixon, Dan A., Lawson, John A., Steinhilber, Dieter, FitzGerald, Garret A., Patrignani, Paola
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2012
Assuntos:
Gastrointestinal, Hepatic, Pulmonary, and Renal
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3310693/
https://ncbi.nlm.nih.gov/pubmed/22262921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.111.190785
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