The Complexity of Sporadic Alzheimer's Disease Pathogenesis: The Role of RAGE as Therapeutic Target to Promote Neuroprotection by Inhibiting Neurovascular Dysfunction

Alzheimer's disease (AD) is the most common cause of dementia. Amyloid plaques and neurofibrillary tangles are prominent pathological features of AD. Aging and age-dependent oxidative stress are the major nongenetic risk factors for AD. The beta-amyloid peptide (Aβ), the major component of plaq...

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Bibliographic Details
Main Authors: Perrone, Lorena, Sbai, Oualid, Nawroth, Peter P., Bierhaus, Angelika
Format: Artigo
Language:Inglês
Published: Hindawi Publishing Corporation 2012
Subjects:
Review Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3310161/
https://ncbi.nlm.nih.gov/pubmed/22482078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/734956
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