cAMP regulates DEP domain-mediated binding of the guanine nucleotide exchange factor Epac1 to phosphatidic acid at the plasma membrane

Epac1 is a cAMP-regulated guanine nucleotide exchange factor for the small G protein Rap. Upon cAMP binding, Epac1 undergoes a conformational change that results in its release from autoinhibition. In addition, cAMP induces the translocation of Epac1 from the cytosol to the plasma membrane. This rel...

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Detalles Bibliográficos
Autores principales: Consonni, Sarah V., Gloerich, Martijn, Spanjaard, Emma, Bos, Johannes L.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2012
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3309772/
https://ncbi.nlm.nih.gov/pubmed/22343288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1117599109
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