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Use of new phosphonylating and coupling agents in the synthesis of oligodeoxyribonucleotides via the H-phosphonate approach.

New phosphonylating and coupling agents for the synthesis of oligodeoxyribonucleotides via H-phosphonate approach have been developed. Tris(1,1,1,3,3,3-hexafluoro-2-propyl) phosphite, prepared by the reaction of lithium salt of 1,1,1,3,3,3-hexafluoro-2-propoxide with PCl3, reacts with deoxyribonucle...

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Autors principals: Sakatsume, O, Yamane, H, Takaku, H, Yamamoto, N
Format: Artigo
Idioma:Inglês
Publicat: 1990
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC330940/
https://ncbi.nlm.nih.gov/pubmed/2356122
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