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Molecular Dynamics Investigation of Cl(−) and Water Transport through a Eukaryotic CLC Transporter
Early crystal structures of prokaryotic CLC proteins identified three Cl(–) binding sites: internal (S(int)), central (S(cen)), and external (S(ext)). A conserved external GLU (GLU(ex)) residue acts as a gate competing for S(ext). Recently, the first crystal structure of a eukaryotic transporter, Cm...
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| Asıl Yazarlar: | , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
The Biophysical Society
2012
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3309281/ https://ncbi.nlm.nih.gov/pubmed/22455919 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2012.01.056 |
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