Cannabinoid Receptor 2-Mediated Attenuation of CXCR4-Tropic HIV Infection in Primary CD4+ T Cells

Agents that activate cannabinoid receptor pathways have been tested as treatments for cachexia, nausea or neuropathic pain in HIV-1/AIDS patients. The cannabinoid receptors (CB(1)R and CB(2)R) and the HIV-1 co-receptors, CCR5 and CXCR4, all signal via Gαi-coupled pathways. We hypothesized that drugs...

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Detalhes bibliográficos
Main Authors: Costantino, Cristina Maria, Gupta, Achla, Yewdall, Alice W., Dale, Benjamin M., Devi, Lakshmi A., Chen, Benjamin K.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3309010/
https://ncbi.nlm.nih.gov/pubmed/22448282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0033961
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