Targeting Acyl-CoA:Diacylglycerol Acyltransferase 1 (DGAT1) with Small Molecule Inhibitors for the Treatment of Metabolic Diseases

Acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) is one of two known DGAT enzymes that catalyze the final step in triglyceride synthesis. Findings from genetically modified mice as well as pharmacological studies suggest that inhibition of DGAT1 is a promising strategy for the treatment of obesity...

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Detalhes bibliográficos
Main Authors: Cao, Jingsong, Zhou, Yingjiang, Peng, Haibing, Huang, Xinyi, Stahler, Shannon, Suri, Vipin, Qadri, Ariful, Gareski, Tiffany, Jones, Juli, Hahm, Seung, Perreault, Mylene, McKew, John, Shi, Mengxiao, Xu, Xin, Tobin, James F., Gimeno, Ruth E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Lipids
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3308890/
https://ncbi.nlm.nih.gov/pubmed/21990351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.245456
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