Mutant Profilin Suppresses Mutant Actin-dependent Mitochondrial Phenotype in Saccharomyces cerevisiae

In the Saccharomyces cerevisiae actin-profilin interface, Ala(167) of the actin barbed end W-loop and His(372) near the C terminus form a clamp around a profilin segment containing residue Arg(81) and Tyr(79). Modeling suggests that altering steric packing in this interface regulates actin activity....

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Bibliographic Details
Main Authors: Wen, Kuo-Kuang, McKane, Melissa, Stokasimov, Ema, Rubenstein, Peter A.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2011
Subjects:
Protein Structure and Folding
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3308883/
https://ncbi.nlm.nih.gov/pubmed/21956104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.217661
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