Structure-guided Inhibitor Design for Human Acetyl-coenzyme A Carboxylase by Interspecies Active Site Conversion

Inhibition of acetyl-CoA carboxylases (ACCs), a crucial enzyme for fatty acid metabolism, has been shown to promote fatty acid oxidation and reduce body fat in animal models. Therefore, ACCs are attractive targets for structure-based inhibitor design, particularly the carboxyltransferase (CT) domain...

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Detaylı Bibliyografya
Asıl Yazarlar: Rajamohan, Francis, Marr, Eric, Reyes, Allan R., Landro, James A., Anderson, Marie D., Corbett, Jeffrey W., Dirico, Kenneth J., Harwood, James H., Tu, Meihua, Vajdos, Felix F.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2011
Konular:
Molecular Bases of Disease
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3308862/
https://ncbi.nlm.nih.gov/pubmed/21953464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.275396
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