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Picomolar Concentrations of Free Zinc(II) Ions Regulate Receptor Protein-tyrosine Phosphatase β Activity

As key enzymes in the regulation of biological phosphorylations, protein-tyrosine phosphatases are central to the control of cellular signaling and metabolism. Zinc(II) ions are known to inhibit these enzymes, but the physiological significance of this inhibition has remained elusive. Employing meta...

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Autori principali: Wilson, Matthew, Hogstrand, Christer, Maret, Wolfgang
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3308757/
https://ncbi.nlm.nih.gov/pubmed/22275360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C111.320796
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