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Beyond amyloid: a diverse portfolio of novel drug discovery programs for Alzheimer's disease and related dementias

Although the molecular mechanisms underlying the pathogenesis of Alzheimer's disease and other related neurodegenerative diseases remain unclear, accumulation of misfolded proteins, neuroinflammation, mitochondrial dysfunction and perturbed calcium homeostasis have been identified as key events...

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Detalhes bibliográficos
Main Authors: Lane, Rachel F, Shineman, Diana W, Fillit, Howard M
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3308025/
https://ncbi.nlm.nih.gov/pubmed/22236739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/alzrt99
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