The Pathophysiological Role of the PKCδ Pathway in the Intervertebral Disc: In vitro, ex vivo and in vivo studies

OBJECTIVE: PKCδ activation was found to be a principal rate-limiting step in matrix-degrading enzyme production in human articular chondrocytes. However, the role of the PKC pathways, specifically PKCδ, has not yet been assessed in intervertebral disc tissue homeostasis. METHODS: Using in vitro, ex...

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Main Authors: Ellman, Michael B, Kim, Jaesung, An, Howard S, Kroin, Jeffrey S., Li, Xin, Chen, Di, Yan, Dongyao, Buechter, Doug D, Nakayama, Keiichi, Liu, Bo, Morganand, Stephanie, Im, Hee-Jeong
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3307815/
https://ncbi.nlm.nih.gov/pubmed/22161873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.34337
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