aPKC phosphorylates JAM-A at Ser285 to promote cell contact maturation and tight junction formation

The PAR-3–atypical protein kinase C (aPKC)–PAR-6 complex has been implicated in the development of apicobasal polarity and the formation of tight junctions (TJs) in vertebrate epithelial cells. It is recruited by junctional adhesion molecule A (JAM-A) to primordial junctions where aPKC is activated...

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Detalhes bibliográficos
Main Authors: Iden, Sandra, Misselwitz, Steve, Peddibhotla, Swetha S.D., Tuncay, Hüseyin, Rehder, Daniela, Gerke, Volker, Robenek, Horst, Suzuki, Atsushi, Ebnet, Klaus
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2012
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3307692/
https://ncbi.nlm.nih.gov/pubmed/22371556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201104143
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