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A 46 base pair enhancer sequence within the locus activating region is required for induced expression of the gamma-globin gene during erythroid differentiation.

The locus activating region (LAR), contained within 30 kb of chromatin flanking the human beta-globin gene cluster, has recently been shown to be essential for high level beta-globin gene expression. To determine the effect of fragments containing LAR sequences on globin gene expression, mRNA from a...

詳細記述

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書誌詳細
主要な著者: Sorrentino, B, Ney, P, Bodine, D, Nienhius, A W
フォーマット: Artigo
言語:Inglês
出版事項: 1990
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC330757/
https://ncbi.nlm.nih.gov/pubmed/2339058
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