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Decarbonylative Approach to the Synthesis of Enamides from Amino Acids: Stereoselective Synthesis of the (Z)-Aminovinyl-D-Cysteine Unit of Mersacidin

[Image: see text] The Pd- and Ni-promoted decarbonylation of amino acid thioesters proceeds smoothly to yield enamides. The synthesis of the (S)-(Z)-AviMeCys subunit of mersacidin, an MRSA-active lantibiotic, via this approach, is described.

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Bibliografske podrobnosti
Main Authors: García-Reynaga, Pablo, Carrillo, Angela K., VanNieuwenhze, Michael S.
Format: Artigo
Jezik:Inglês
Izdano: 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3307523/
https://ncbi.nlm.nih.gov/pubmed/22296268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol203399x
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