Notch Signal Suppresses Toll-like Receptor-triggered Inflammatory Responses in Macrophages by Inhibiting Extracellular Signal-regulated Kinase 1/2-mediated Nuclear Factor κB Activation

Multiple signaling pathways are involved in the tight regulation of Toll-like receptor (TLR) signaling, which is important for the tailoring of inflammatory response to pathogens in macrophages. It is widely accepted that TLR signaling can activate Notch pathway; however, whether full activation of...

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Hlavní autoři: Zhang, Qinghua, Wang, Chunmei, Liu, Zhaolong, Liu, Xingguang, Han, Chaofeng, Cao, Xuetao, Li, Nan
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2012
Témata:
Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3307302/
https://ncbi.nlm.nih.gov/pubmed/22205705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.310375
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