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Productive Recognition of Factor IX by Factor XIa Exosites Requires Disulfide Linkage between Heavy and Light Chains of Factor XIa

In the intrinsic pathway of blood coagulation factor XIa (FXIa) activates factor IX (FIX) by cleaving the zymogen at Arg(145)-Ala(146) and Arg(180)-Val(181) bonds releasing an 11-kDa activation peptide. FXIa and its isolated light chain (FXIa-LC) cleave S-2366 at comparable rates, but FXIa-LC is a v...

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Autors principals: Marcinkiewicz, Mariola M., Sinha, Dipali, Walsh, Peter N.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3307291/
https://ncbi.nlm.nih.gov/pubmed/22207756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.291989
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