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Differential Effects of a Dual Orexin Receptor Antagonist (SB-649868) and Zolpidem on Sleep Initiation and Consolidation, SWS, REM Sleep, and EEG Power Spectra in a Model of Situational Insomnia

Orexins have a role in sleep regulation, and orexin receptor antagonists are under development for the treatment of insomnia. We conducted a randomised, double-blind, placebo-controlled, four-period crossover study to investigate the effect of single doses of the dual orexin receptor antagonist SB-6...

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Autores principales: Bettica, Paolo, Squassante, Lisa, Groeger, John A, Gennery, Brian, Winsky-Sommerer, Raphaelle, Dijk, Derk-Jan
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2012
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3306884/
https://ncbi.nlm.nih.gov/pubmed/22237311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2011.310
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