Inhibition of Stabilin-2 elevates circulating hyaluronic acid levels and prevents tumor metastasis

Hyaluronic acid (HA) has been implicated in the proliferation and metastasis of tumor cells. However, most previous studies were conducted on extracellular matrix or pericellular HA, and the role of circulating HA in vivo has not been studied. HA is rapidly cleared from the bloodstream. The scavenge...

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Detalhes bibliográficos
Main Authors: Hirose, Yoshikazu, Saijou, Eiko, Sugano, Yasuyoshi, Takeshita, Fumitaka, Nishimura, Satoshi, Nonaka, Hidenori, Chen, Yen-Rong, Sekine, Keisuke, Kido, Taketomo, Nakamura, Takashi, Kato, Shigeaki, Kanke, Toru, Nakamura, Koji, Nagai, Ryozo, Ochiya, Takahiro, Miyajima, Atsushi
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3306694/
https://ncbi.nlm.nih.gov/pubmed/22371575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1117560109
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