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Mouse B-Type Lamins Are Required for Proper Organogenesis But Not by Embryonic Stem Cells

B-type lamins, the major components of the nuclear lamina, are believed to be essential for cell proliferation and survival. We found that mouse embryonic stem cells (ESCs) do not need any lamins for self-renewal and pluripotency. Although genome-wide lamin-B binding profiles correlate with reduced...

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Bibliografiske detaljer
Main Authors: Kim, Youngjo, Sharov, Alexei A., McDole, Katie, Cheng, Melody, Hao, Haiping, Fan, Chen-Ming, Gaiano, Nicholas, Ko, Minoru S. H., Zheng, Yixian
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3306219/
https://ncbi.nlm.nih.gov/pubmed/22116031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1211222
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