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CYSL-1 Interacts with the O(2)-sensing Hydroxylase EGL-9 to Promote H(2)S-modulated Hypoxia-induced Behavioral Plasticity in C. elegans
The C. elegans HIF-1 proline hydroxylase EGL-9 functions as an O(2)-sensor in an evolutionarily conserved pathway for adaptation to hypoxia. H(2)S accumulates during hypoxia and promotes HIF-1 activity, but how H2S signals are perceived and transmitted to modulate HIF-1 and animal behavior is unknow...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3305813/ https://ncbi.nlm.nih.gov/pubmed/22405203 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2011.12.037 |
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