Highly Sensitive and Specific Detection of Rare Variants in Mixed Viral Populations from Massively Parallel Sequence Data

Viruses diversify over time within hosts, often undercutting the effectiveness of host defenses and therapeutic interventions. To design successful vaccines and therapeutics, it is critical to better understand viral diversification, including comprehensively characterizing the genetic variants in v...

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Detalhes bibliográficos
Main Authors: Macalalad, Alexander R., Zody, Michael C., Charlebois, Patrick, Lennon, Niall J., Newman, Ruchi M., Malboeuf, Christine M., Ryan, Elizabeth M., Boutwell, Christian L., Power, Karen A., Brackney, Doug E., Pesko, Kendra N., Levin, Joshua Z., Ebel, Gregory D., Allen, Todd M., Birren, Bruce W., Henn, Matthew R.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3305335/
https://ncbi.nlm.nih.gov/pubmed/22438797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1002417
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