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Purification to homogeneity and partial amino acid sequence of a fragment which includes the methyl acceptor site of the human DNA repair protein for O6-methylguanine.

DNA repair by O6-methylguanine-DNA methyltransferase (O6-MT) is accomplished by removal by the enzyme of the methyl group from premutagenic O6-methylguanine-DNA, thereby restoring native guanine in DNA. The methyl group is transferred to an acceptor site cysteine thiol group in the enzyme, which cau...

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Bibliografiske detaljer
Main Authors: Major, G N, Gardner, E J, Carne, A F, Lawley, P D
Format: Artigo
Sprog:Inglês
Udgivet: 1990
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC330497/
https://ncbi.nlm.nih.gov/pubmed/2109306
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