Acquisition of EMT phenotype in the gefitinib-resistant cells of a head and neck squamous cell carcinoma cell line through Akt/GSK-3β/snail signalling pathway

BACKGROUND: Epithelial mesenchymal transition (EMT) is known to be associated with chemoresistance as well as increased invasion/metastasis. However, the relationship between EMT and resistance to an epidermal growth factor receptor (EGFR) -targeting drug in head and neck squamous cell carcinoma (HN...

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Autores principales: Maseki, S, Ijichi, K, Tanaka, H, Fujii, M, Hasegawa, Y, Ogawa, T, Murakami, S, Kondo, E, Nakanishi, H
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2012
Materias:
Molecular Diagnostics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3304404/
https://ncbi.nlm.nih.gov/pubmed/22315058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2012.24
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