Reduced 4-Aminobiphenyl-Induced Liver Tumorigenicity but not DNA Damage in Arylamine N-Acetyltransferase Null Mice

The aromatic amine 4-aminobiphenyl (ABP) is a liver procarcinogen in mice, requiring enzymatic bioactivation to exert its tumorigenic effect. To assess the role of arylamine N-acetyltransferase (NAT)-dependent acetylation capacity in the risk for ABP-induced liver tumors, we compared 1-year liver tu...

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Detalhes bibliográficos
Main Authors: Sugamori, Kim S., Brenneman, Debbie, Sanchez, Otto, Doll, Mark A., Hein, David W., Pierce, William M., Grant, Denis M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3303986/
https://ncbi.nlm.nih.gov/pubmed/22193722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2011.12.022
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