Activation of the Nipah Virus Fusion Protein in MDCK Cells Is Mediated by Cathepsin B within the Endosome-Recycling Compartment

Proteolytic activation of the fusion protein of the highly pathogenic Nipah virus (NiV F) is a prerequisite for the production of infectious particles and for virus spread via cell-to-cell fusion. Unlike other paramyxoviral fusion proteins, functional NiV F activation requires endocytosis and pH-dep...

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Main Authors: Diederich, Sandra, Sauerhering, Lucie, Weis, Michael, Altmeppen, Hermann, Schaschke, Norbert, Reinheckel, Thomas, Erbar, Stephanie, Maisner, Andrea
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Microbiology 2012
Ábhair:
Virus-Cell Interactions
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3302499/
https://ncbi.nlm.nih.gov/pubmed/22278224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.06628-11
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