Combination of Biological Screening in a Cellular Model of Viral Latency and Virtual Screening Identifies Novel Compounds That Reactivate HIV-1

Although highly active antiretroviral therapy (HAART) has converted HIV into a chronic disease, a reservoir of HIV latently infected resting T cells prevents the eradication of the virus from patients. To achieve eradication, HAART must be combined with drugs that reactivate the dormant viruses. We...

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Detalhes bibliográficos
Main Authors: Gallastegui, Edurne, Marshall, Brett, Vidal, David, Sanchez-Duffhues, Gonzalo, Collado, Juan A., Alvarez-Fernández, Carmen, Luque, Neus, Terme, Jean-Michel, Gatell, Josep M., Sánchez-Palomino, Sonsoles, Muñoz, Eduardo, Mestres, Jordi, Verdin, Eric, Jordan, Albert
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3302487/
https://ncbi.nlm.nih.gov/pubmed/22258251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.05972-11
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