A Non-Mouse-Adapted Enterovirus 71 (EV71) Strain Exhibits Neurotropism, Causing Neurological Manifestations in a Novel Mouse Model of EV71 Infection

Enterovirus 71 (EV71) is a neurotropic pathogen that has been consistently associated with the severe neurological forms of hand, foot, and mouth disease. The lack of a relevant animal model has hampered our understanding of EV71 pathogenesis, in particular the route and mode of viral dissemination....

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Detalhes bibliográficos
Main Authors: Khong, Wei Xin, Yan, Benedict, Yeo, Huimin, Tan, Eng Lee, Lee, Jia Jun, Ng, Jowin K. W., Chow, Vincent T., Alonso, Sylvie
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3302383/
https://ncbi.nlm.nih.gov/pubmed/22130542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.06103-11
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