Postexposure Treatment with the Live-Attenuated Rabies Virus (RV) Vaccine TriGAS Triggers the Clearance of Wild-Type RV from the Central Nervous System (CNS) through the Rapid Induction of Genes Relevant to Adaptive Immunity in CNS Tissues

Postexposure treatment (PET) of wild-type rabies virus (RV)-infected mice with a live-attenuated triple-glycoprotein RV variant (TriGAS) promotes survival but does not prevent the pathogenic RV from invading and replicating in the brain. Successful PET is associated with the induction of a robust vi...

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Bibliographic Details
Main Authors: Li, Jianwei, Ertel, Adam, Portocarrero, Carla, Barkhouse, Darryll A., Dietzschold, Bernhard, Hooper, D. Craig, Faber, Milosz
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2012
Subjects:
Vaccines and Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3302305/
https://ncbi.nlm.nih.gov/pubmed/22238315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.06699-11
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