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Attenuation of Neurovirulence, Biodistribution, and Shedding of a Poliovirus:Rhinovirus Chimera after Intrathalamic Inoculation in Macaca fascicularis

A dependence of poliovirus on an unorthodox translation initiation mode can be targeted selectively to drive viral protein synthesis and cytotoxicity in malignant cells. Transformed cells are naturally susceptible to poliovirus, due to widespread ectopic upregulation of the poliovirus receptor, Necl...

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Bibliografiske detaljer
Main Authors: Dobrikova, Elena Y., Goetz, Christian, Walters, Robert W., Lawson, Sarah K., Peggins, James O., Muszynski, Karen, Ruppel, Sheryl, Poole, Karyol, Giardina, Steven L., Vela, Eric M., Estep, James E., Gromeier, Matthias
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3302279/
https://ncbi.nlm.nih.gov/pubmed/22171271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.06427-11
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