Specific Mutation of a Gammaherpesvirus-Expressed Antigen in Response to CD8 T Cell Selection In Vivo

Herpesviruses are thought to be highly genetically stable, and their use as vaccine vectors has been proposed. However, studies of the human gammaherpesvirus, Epstein-Barr virus, have found viral isolates containing mutations in HLA class I-restricted epitopes. Using murine gammaherpesvirus 68 expre...

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Bibliographic Details
Main Authors: Loh, Joy, Popkin, Daniel L., Droit, Lindsay, Braaten, Douglas C., Zhao, Guoyan, Zhang, Xin, Vachharajani, Punit, Myers, Nancy, Hansen, Ted H., Virgin, Herbert W.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2012
Subjects:
Genetic Diversity and Evolution
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3302239/
https://ncbi.nlm.nih.gov/pubmed/22171269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.06101-11
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