Metformin mitigates the impaired development of skeletal muscle in the offspring of obese mice

Background: Maternal obesity is linked with offspring obesity and type 2 diabetes. Skeletal muscle (SM) insulin resistance is central to the development of diabetes. Adenosine monophosphate (AMP)-activated protein kinase (AMPK) is inhibited in SM of fetuses born to obese mothers. Objective: The aim...

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Detalhes bibliográficos
Main Authors: Tong, J F, Yan, X, Zhao, J X, Zhu, M J, Nathanielsz, P W, Du, M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3302133/
https://ncbi.nlm.nih.gov/pubmed/23449382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nutd.2011.3
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