Interleukin-1 receptor antagonist and tumor necrosis factor binding protein decrease osteoclast formation and bone resorption in ovariectomized mice.

To investigate the contribution of IL-1, IL-6, and TNF to the increased osteoclastogenesis induced by estrogen deficiency, ovariectomized (ovx) mice were treated with either IL-1 receptor antagonist (IL-1ra), a competitive inhibitor of IL-1, TNF binding protein (TNFbp), an inhibitor of TNF, or the a...

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Detalhes bibliográficos

Publicado no:	J Clin Invest
Principais autores:	Kitazawa, R, Kimble, R B, Vannice, J L, Kung, V T, Pacifici, R
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 1994
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC330070/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7989596/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI117606
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